Ssri activating sedating

AD's more stimulating than Bupropion include: Reboxetine, Protriptyline and possibly Desipramine.Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs which are used in the treatment of major depressive disorder (MDD).Since the late 1980s, SSRIs have dominated the antidepressant drug market.Today, there is increased interest in antidepressant drugs with broader mechanisms of action that may offer improvements in efficacy and fewer adverse effects.Researchers noted that patients given iproniazid became cheerful, more optimistic, and more physically active.Soon after its development, iproniazid and related substances were shown to slow enzymatic breakdown of serotonin, dopamine, and norepinephrine via inhibition of the enzyme monoamine oxidase.

During this time development of distinctively different antidepressant agents was also researched.

SNRIs, along with selective serotonin reuptake inhibitors (SSRIs) and norepinephrine reuptake inhibitors (NRIs), are second-generation antidepressants.

Over the past two decades, second-generation antidepressants have gradually replaced first-generation antidepressants, such as tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) as the drugs of choice for the treatment of MDD.

This is mainly because of their improved tolerability and safety profile.

A closely related type of drug is a serotonin–norepinephrine releasing agent (SNRA), for instance the withdrawn appetite suppressant fenfluramine/phentermine (Fen-Phen).

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These substances are unrelated to TCA and other SSRIs.

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